Vardenafil vs Sildenafil Citrate: side-by-side comparison
Vardenafil and Sildenafil Citrate belong to the same class (PDE5 inhibitor). They share therapeutic approach but differ in mechanism nuances, half-life, side-effect profile and available formulations. This comparison summarises what is common and where they diverge.
| Property | Vardenafil | Sildenafil Citrate |
|---|---|---|
| Therapeutic class | PDE5 inhibitor | PDE5 inhibitor |
| CAS | 224785-91-5 | 171599-83-0 |
| ATC | G04BE09 | G04BE03 |
| Molecular weight | 488.6 g/mol | 666.7 g/mol |
| Brands with this active ingredient | 2 | 10 |
What they share
Both are in the PDE5 inhibitor class, giving them a common pharmacological architecture and many shared safety and management points. Choice within the class comes down to mechanism nuances, half-life, side-effect profile and individual response.
Key differences
Differences within the PDE5 inhibitor class are what matter in practice: half-life, route of administration, equivalent doses, specific interactions, predominant side-effect profile and accumulated clinical experience. This page frames them; the prescribing information gives quantitative detail.
Mechanisms compared
Vardenafil: Le vardénafil inhibe sélectivement la PDE5, l'enzyme qui dégrade le guanosine monophosphate cyclique dans le corps caverneux. Sildenafil Citrate: Le citrate de sildénafil inhibe sélectivement la phosphodiestérase de type 5 (PDE5), l'enzyme qui dégrade le guanosine monophosphate cyclique dans le corps caverneux.
Indications compared
Vardenafil: Le vardénafil est autorisé chez l'homme adulte dans le traitement de la dysfonction érectile. Sildenafil Citrate: Le citrate de sildénafil est autorisé chez l'homme adulte dans le traitement de la dysfonction érectile.
Safety profile
Vardenafil: Les effets indésirables fréquents observés dans les essais cliniques comprennent céphalées, bouffées vasomotrices du visage, congestion nasale, dyspepsie et vertiges. Sildenafil Citrate: Les effets indésirables fréquents rapportés dans les essais cliniques comprennent céphalées, bouffées vasomotrices du visage, congestion nasale, dyspepsie et troubles visuels transitoires.
Questions fréquentes
Is Vardenafil better than Sildenafil Citrate? ▾
Neither is universally better. Vardenafil and Sildenafil Citrate share the PDE5 inhibitor class but differ in half-life, mechanism nuances and side-effect profile. The choice depends on the patient and the prescriber.
Can Vardenafil and Sildenafil Citrate be combined? ▾
Combining two ingredients from the same PDE5 inhibitor class is uncommon and, in most cases, adds no benefit over one at an appropriate dose. The decision is always the prescriber's.
Do they have the same side-effect profile? ▾
Partly yes — they share many PDE5 inhibitor class effects, with nuances by mechanism and dose. The prescribing information lists differences.
Products with Vardenafil
Products with Sildenafil Citrate
Les informations publiées sur ce site sont fournies à titre documentaire et pédagogique. Elles ne remplacent pas l'avis d'un professionnel de santé qualifié.