Vardenafil vs Sildenafil Citrate: side-by-side comparison
Vardenafil and Sildenafil Citrate belong to the same class (PDE5 inhibitor). They share therapeutic approach but differ in mechanism nuances, half-life, side-effect profile and available formulations. This comparison summarises what is common and where they diverge.
| Property | Vardenafil | Sildenafil Citrate |
|---|---|---|
| Therapeutic class | PDE5 inhibitor | PDE5 inhibitor |
| CAS | 224785-91-5 | 171599-83-0 |
| ATC | G04BE09 | G04BE03 |
| Molecular weight | 488.6 g/mol | 666.7 g/mol |
| Brands with this active ingredient | 2 | 10 |
What they share
Both are in the PDE5 inhibitor class, giving them a common pharmacological architecture and many shared safety and management points. Choice within the class comes down to mechanism nuances, half-life, side-effect profile and individual response.
Key differences
Differences within the PDE5 inhibitor class are what matter in practice: half-life, route of administration, equivalent doses, specific interactions, predominant side-effect profile and accumulated clinical experience. This page frames them; the prescribing information gives quantitative detail.
Mechanisms compared
Vardenafil: Vardenafil hemmt selektiv die PDE5, das Enzym, das zyklisches Guanosinmonophosphat im Corpus cavernosum abbaut. Sildenafil Citrate: Sildenafilcitrat hemmt selektiv die Phosphodiesterase Typ 5 (PDE5), ein Enzym, das zyklisches Guanosinmonophosphat im Corpus cavernosum abbaut.
Indications compared
Vardenafil: Vardenafil ist bei erwachsenen Männern zur Behandlung der erektilen Dysfunktion zugelassen. Sildenafil Citrate: Sildenafilcitrat ist bei erwachsenen Männern zur Behandlung der erektilen Dysfunktion zugelassen.
Safety profile
Vardenafil: Häufige Nebenwirkungen in klinischen Studien sind Kopfschmerzen, Gesichtsrötung, verstopfte Nase, Dyspepsie und Schwindel. Sildenafil Citrate: Häufige unerwünschte Wirkungen aus klinischen Studien umfassen Kopfschmerzen, Gesichtsrötung, Nasenschleimhautschwellung, Dyspepsie und vorübergehende Sehstörungen.
Häufig gestellte Fragen
Is Vardenafil better than Sildenafil Citrate? ▾
Neither is universally better. Vardenafil and Sildenafil Citrate share the PDE5 inhibitor class but differ in half-life, mechanism nuances and side-effect profile. The choice depends on the patient and the prescriber.
Can Vardenafil and Sildenafil Citrate be combined? ▾
Combining two ingredients from the same PDE5 inhibitor class is uncommon and, in most cases, adds no benefit over one at an appropriate dose. The decision is always the prescriber's.
Do they have the same side-effect profile? ▾
Partly yes — they share many PDE5 inhibitor class effects, with nuances by mechanism and dose. The prescribing information lists differences.
Products with Vardenafil
Products with Sildenafil Citrate
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