Atypical antidepressant (NaSSA)
Who should not take Mirtazapine
A contraindication is a condition under which Mirtazapine (Mirtazapine) should not be taken because the risk outweighs the benefit. Mirtazapine has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 7.5mg, 15mg, 30mg, 45mg dosing range.
Absolute contraindications
According to the prescribing information for Mirtazapine, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Mirtazapine can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Mirtazapine antagonises presynaptic α2-adrenergic autoreceptors and heteroreceptors, increasing noradrenaline and serotonin release.
Frequently asked questions
Can someone with heart disease take Mirtazapine? ▾
Some forms of heart disease are absolute contraindications for Mirtazapine, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Mirtazapine use under specialist supervision. The prescribing information for Mirtazapine should be reviewed.
Is Mirtazapine safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Mirtazapine at adjusted lower 7.5mg, 15mg, 30mg, 45mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Mirtazapine
More on Mirtazapine
- With alcoholMirtazapine and alcohol — is it safe to drink?
- With foodShould Mirtazapine be taken with food?
- Side effectsMirtazapine side effects: common, rare and warning signs
- Dosage guideMirtazapine dosage guide: how much to take and when
- OnsetHow fast does Mirtazapine start working?
- DurationHow long does Mirtazapine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.