Cymbalta with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Cymbalta (Duloxetine). The combination is generally fine at 20mg, 30mg, 60mg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Cymbalta can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Duloxetine acts on CYP3A4 determines whether Cymbalta affects contraception. Most agents in Anti-Depressants have no clinically meaningful effect on the pill at 20mg, 30mg, 60mg.
Practical guidance
According to the prescribing information for Duloxetine, women on hormonal contraception should review Cymbalta with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Cymbalta therapy is the standard mitigation.
Frequently asked questions
Will Cymbalta make my pill less effective? ▾
Most Anti-Depressants medications at 20mg, 30mg, 60mg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Duloxetine states whether the interaction is meaningful.
Do I need a backup contraceptive on Cymbalta? ▾
Backup contraception is needed only when there is a documented interaction between Cymbalta and the contraceptive method. For most users at 20mg, 30mg, 60mg, no backup is required. The pharmacist confirms whether Duloxetine interacts with hormonal contraception.
More on Cymbalta
- With alcoholCymbalta and alcohol — is it safe to drink?
- With foodShould Cymbalta be taken with food?
- Side effectsCymbalta side effects: common, rare and warning signs
- Dosage guideCymbalta dosage guide: how much to take and when
- OnsetHow fast does Cymbalta start working?
- DurationHow long does Cymbalta last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.