Who should not take Anti-Depressants
A contraindication is a condition under which Anti-Depressants (Anti-Depressants) should not be taken because the risk outweighs the benefit. Anti-Depressants has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 10mg, 20mg, 40mg, 30mg, 60mg dosing range.
Absolute contraindications
According to the prescribing information for Amitriptyline, Bupropion, Citalopram, Duloxetine, Escitalopram, Fluoxetine, Mirtazapine, Paroxetine, Sertraline, Trazodone, Venlafaxine, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Anti-Depressants can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Selective serotonin reuptake inhibitors (SSRIs) are the most common first-line option for depression and anxiety due to their generally favourable side effect profile.
Frequently asked questions
Can someone with heart disease take Anti-Depressants? ▾
Some forms of heart disease are absolute contraindications for Anti-Depressants, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Anti-Depressants use under specialist supervision. The prescribing information for Amitriptyline, Bupropion, Citalopram, Duloxetine, Escitalopram, Fluoxetine, Mirtazapine, Paroxetine, Sertraline, Trazodone, Venlafaxine should be reviewed.
Is Anti-Depressants safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Anti-Depressants at adjusted lower 10mg, 20mg, 40mg, 30mg, 60mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Medications in Anti-Depressants
More on Anti-Depressants
- With alcoholAnti-Depressants and alcohol — is it safe to drink?
- With foodShould Anti-Depressants be taken with food?
- Side effectsAnti-Depressants side effects: common, rare and warning signs
- For older adultsAnti-Depressants after 60: doses and safety in older adults
- For womenAnti-Depressants for women: indications and considerations
- For menAnti-Depressants for men: indications and considerations
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.