Lexapro vs Sertraline: brand vs ingredient
Lexapro contains Escitalopram, while Sertraline is a different active ingredient in the Selective serotonin reuptake inhibitor (SSRI) class. This page compares them: when each is used, how the mechanisms and indications differ, and whether the question "Lexapro vs Sertraline" makes sense to ask at all.
What is the relationship?
Lexapro and Sertraline are different things: Lexapro is a branded medication whose active ingredient is Escitalopram (in the Antidépresseurs class), whereas Sertraline is in the Selective serotonin reuptake inhibitor (SSRI) class. They share a common therapeutic context and are sometimes weighed in the same clinical decision.
When Lexapro is used
Lexapro est autorisé dans la dépression caractérisée et le trouble anxieux généralisé chez l'adulte, ainsi que chez l'adolescent à partir de 12 ans pour la dépression.
When Sertraline is used
La sertraline est autorisée dans plusieurs indications psychiatriques chez l'adulte : dépression caractérisée, trouble panique avec ou sans agoraphobie, trouble obsessionnel compulsif (TOC), état de stress post-traumatique, anxiété sociale…
Mechanisms compared
Lexapro: Lexapro agit en inhibant sélectivement le transporteur de recapture de la sérotonine (SERT) au niveau de la synapse, augmentant la disponibilité de la sérotonine pour les récepteurs postsynaptiques. Sertraline: La sertraline bloque sélectivement la recapture de la sérotonine (5-HT) par le neurone présynaptique, ce qui augmente la concentration de sérotonine dans la fente synaptique.
When the comparison makes sense
Comparing Lexapro with Sertraline makes sense when both are in the same clinical decision: they belong to the same therapeutic class and may be considered as alternatives. If the question is between two options for the same need, the prescriber decides based on prior response, comorbidities and tolerance.
Questions fréquentes
Do Lexapro and Sertraline treat the same thing? ▾
They treat partially overlapping conditions, both in the Antidépresseurs area. The question of which to use is for the prescriber to answer based on the specific indication.
Can Lexapro and Sertraline be combined? ▾
It depends on the interaction profile of Escitalopram with Sertraline. If both are in a single prescription, the prescriber has weighed it. Self-medicating with both is not recommended without pharmacist review.
Which is better, Lexapro or Sertraline? ▾
"Better" doesn't apply between medications for different indications. The sensible question is which fits your specific clinical need — that is the prescriber's call.
Les informations publiées sur ce site sont fournies à titre documentaire et pédagogique. Elles ne remplacent pas l'avis d'un professionnel de santé qualifié.