Klonopin vs Ativan: side-by-side comparison
Klonopin (Clonazepam) and Ativan (Lorazepam) both belong to the Anxiolytiques class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Klonopin | Ativan |
|---|---|---|
| Active ingredient | Clonazepam | Lorazepam |
| Manufacturer | Genentech (Roche) | Pfizer |
| Class | Anxiolytiques | Anxiolytiques |
| Strengths | 0.5mg, 1mg, 2mg | 0.5mg, 1mg, 2mg |
| Forms | tablet, orally disintegrating tablet | tablet, oral concentrate, injection |
What's the same
Klonopin and Ativan both belong to the Anxiolytiques class and are used for partially overlapping indications. The active ingredients — Clonazepam vs Lorazepam — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Clonazepam vs Lorazepam), strengths (0.5mg, 1mg, 2mg vs 0.5mg, 1mg, 2mg), forms (tablet, orally disintegrating tablet vs tablet, oral concentrate, injection), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Klonopin: Le clonazépam se lie au site benzodiazépine du récepteur GABA-A et renforce de façon allostérique la conductance chlorure inhibitrice, hyperpolarisant les neurones du système nerveux central. Ativan: Le lorazépam se lie au site benzodiazépine du récepteur GABA-A et renforce de façon allostérique la conductance chlorure inhibitrice.
When Klonopin is preferred
Klonopin est autorisé chez l'adulte dans le traitement de certains types de crises épileptiques, dont les absences et absences atypiques, les crises myocloniques et akinétiques, ainsi qu'en traitement adjuvant du syndrome de Lennox-Gastaut.
When Ativan is preferred
Ativan est autorisé chez l'adulte dans la prise en charge de courte durée des troubles anxieux et de l'insomnie liée à l'anxiété.
Questions fréquentes
Is Klonopin or Ativan better? ▾
There is no single answer. Klonopin and Ativan both belong to the Anxiolytiques class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Klonopin to Ativan? ▾
Switching within the Anxiolytiques class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Klonopin and Ativan have the same side effects? ▾
They share many of the Anxiolytiques class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Klonopin comparisons
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