Synthetic steroid (STEAR)
Tibolone with liver impairment: dosing and safety
The liver is the main site of metabolism for many medications including Tibolone (Tibolone). Liver impairment slows clearance and can raise plasma levels of Tibolone above the intended range, amplifying side effects. People with chronic liver disease, recent hepatitis or significantly raised liver enzymes need a tailored approach to Tibolone at 2.5mg.
Why liver function matters
Tibolone undergoes hepatic metabolism through CYP enzymes for many medications. Reduced hepatic function slows this metabolism, prolongs the half-life and raises plasma concentrations. Tibolone is a prodrug; on absorption it is rapidly converted to three active metabolites (3α-OH-tibolone, 3β-OH-tibolone and Δ4-tibolone) with different tissue-selective activity. The prescribing information typically classifies severity by Child-Pugh score (A mild, B moderate, C severe) and gives dose adjustments accordingly.
Practical guidance
According to the prescribing information for Tibolone, baseline liver function tests are recommended before starting Tibolone in any patient with risk factors and periodically during treatment in chronic liver disease. Severe impairment (Child-Pugh C) often contraindicates Tibolone or requires substantial dose reduction; mild impairment usually permits standard 2.5mg with closer monitoring.
Frequently asked questions
Is Tibolone safe with liver problems? ▾
Mild liver impairment typically allows Tibolone at standard or slightly reduced 2.5mg with monitoring. Moderate-to-severe impairment often requires substantial dose reduction. Severe (Child-Pugh C) impairment may contraindicate Tibolone entirely.
Will Tibolone damage my liver? ▾
Most Synthetic steroid (STEAR) medications at standard 2.5mg doses do not harm a healthy liver. A small subset can produce drug-induced liver injury in susceptible patients, usually detected by routine ALT/AST monitoring. The prescribing information for Tibolone lists the documented risk.
Products containing Tibolone
More on Tibolone
- With alcoholTibolone and alcohol — is it safe to drink?
- With foodShould Tibolone be taken with food?
- Side effectsTibolone side effects: common, rare and warning signs
- Dosage guideTibolone dosage guide: how much to take and when
- OnsetHow fast does Tibolone start working?
- DurationHow long does Tibolone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.