Selective serotonin reuptake inhibitor (SSRI)
Sertraline with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Sertraline (Sertraline). Most antibiotics do not interfere meaningfully with Sertraline at 25mg, 50mg, 100mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Selective serotonin reuptake inhibitor (SSRI) agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Sertraline at 25mg, 50mg, 100mg.
Practical guidance
According to the prescribing information for Sertraline, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Sertraline is co-administered. Adjusted 25mg, 50mg, 100mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Sertraline during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Sertraline is metabolised and may need a temporary 25mg, 50mg, 100mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Sertraline regimen.
Will antibiotics make Sertraline stop working? ▾
Most antibiotics do not affect Sertraline efficacy. Rifampicin and a few others can lower Sertraline levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Sertraline
More on Sertraline
- With alcoholSertraline and alcohol — is it safe to drink?
- With foodShould Sertraline be taken with food?
- Side effectsSertraline side effects: common, rare and warning signs
- Dosage guideSertraline dosage guide: how much to take and when
- OnsetHow fast does Sertraline start working?
- DurationHow long does Sertraline last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.