Selective serotonin reuptake inhibitor (SSRI)
Sertraline and surgery: what to do before and after
Surgery raises specific medication-management questions, and getting the answer right matters because both unintended drug interactions during anaesthesia and abrupt discontinuation of important chronic therapies carry risk. Whether Sertraline (Sertraline) needs to be stopped before surgery, continued through, or paused for a defined window depends on Sertraline and the type of procedure.
Before-surgery decision
For most chronic medications including many Selective serotonin reuptake inhibitor (SSRI) agents, the surgical team or anaesthetist makes the stop-or-continue decision during pre-op assessment. Considerations include bleeding risk, anaesthesia interactions, the urgency of the underlying condition and the type of procedure. According to most guidelines, surprises are avoided by listing all medications including Sertraline at 25mg, 50mg, 100mg on the pre-op form.
After surgery
Post-operative resumption of Sertraline depends on the surgical course, the medication's impact on recovery (e.g. wound healing, gastric tolerance, mobility) and any new prescriptions added after surgery. Sertraline selectively blocks the reuptake of serotonin (5-HT) by the presynaptic neuron, increasing the concentration of serotonin in the synaptic cleft. Resuming on schedule is usually the goal as soon as oral intake and clinical stability allow.
Frequently asked questions
Do I need to stop Sertraline before surgery? ▾
It depends on Sertraline and the procedure. The pre-op assessment is where this is decided, ideally a week or more before surgery. Bring the full medication list including Sertraline at 25mg, 50mg, 100mg so the team can advise.
When can I restart Sertraline after surgery? ▾
Resumption timing depends on the procedure, the recovery course and any interactions with new postoperative medications. Many patients restart Sertraline on the day of discharge or earlier; some need a longer pause. The surgical team or prescriber confirms the timing.
Products containing Sertraline
More on Sertraline
- With alcoholSertraline and alcohol — is it safe to drink?
- With foodShould Sertraline be taken with food?
- Side effectsSertraline side effects: common, rare and warning signs
- Dosage guideSertraline dosage guide: how much to take and when
- OnsetHow fast does Sertraline start working?
- DurationHow long does Sertraline last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.