Selective serotonin reuptake inhibitor (SSRI)
Sertraline side effects: common, rare and warning signs
Like any active medication, Sertraline (Sertraline) can produce side effects. Most are mild and transient at the standard 25mg, 50mg, 100mg dose, but a small subset are serious and call for stopping the medication and seeking medical help. This page summarises what is typical, what is rare, and what should never be ignored.
Common side effects of Sertraline
According to the prescribing information for Sertraline, the most frequent side effects are usually dose-related and resolve on their own within hours of dosing. They typically reflect the medication's mechanism: Sertraline selectively blocks the reuptake of serotonin (5-HT) by the presynaptic neuron, increasing the concentration of serotonin in the synaptic cleft. For most users on Sertraline at 25mg, 50mg, 100mg, side effects fade as the body adjusts, often within the first few weeks of regular use.
Serious or warning signs
Rare but serious adverse effects deserve immediate medical attention. These include severe allergic reactions, sudden vision or hearing changes, chest pain, prolonged or painful effects on cardiovascular tissue, severe abdominal pain or signs of bleeding. Anyone experiencing these on Sertraline should stop the medication and contact emergency services or a healthcare provider promptly.
Frequently asked questions
Are Sertraline side effects dangerous? ▾
For most people on a routine 25mg, 50mg, 100mg dose, side effects are mild and short-lived. Serious adverse events are rare but real; severe allergic reactions, chest pain, sudden visual changes or other unusual symptoms are signals to stop and seek medical help.
Do Sertraline side effects go away? ▾
Most common side effects of Sertraline resolve on their own within hours of each dose or fade over the first weeks of regular use as the body adjusts. Persistent or worsening side effects should be reviewed with the prescriber, who can adjust the dose or switch the medication.
Products containing Sertraline
More on Sertraline
- With alcoholSertraline and alcohol — is it safe to drink?
- With foodShould Sertraline be taken with food?
- Dosage guideSertraline dosage guide: how much to take and when
- OnsetHow fast does Sertraline start working?
- DurationHow long does Sertraline last?
- Missed doseWhat to do if you miss a dose of Sertraline
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.