Selective serotonin reuptake inhibitor (SSRI)
Sertraline dosage guide: how much to take and when
Choosing the right dose of Sertraline (Sertraline) is the most important practical decision after starting therapy. Sertraline is supplied as tablet in 25mg, 50mg, 100mg, and the right dose for a given person depends on the indication, age, comorbidities and tolerance to the active ingredient Sertraline.
Starting dose and titration
According to the prescribing information, most adults begin Sertraline at the lowest available strength of 25mg, 50mg, 100mg and titrate up only if symptom control is insufficient and tolerability is good. Higher doses are reserved for selected cases. Older adults, people with renal or hepatic impairment, and those taking interacting medications should usually start at the lowest dose.
When to adjust
Dose adjustment is guided by symptom response and side effect burden, not by arbitrary schedules. Sertraline selectively blocks the reuptake of serotonin (5-HT) by the presynaptic neuron, increasing the concentration of serotonin in the synaptic cleft. If side effects are limiting at a given dose, going down a step is usually preferred over stopping abruptly. If the response is incomplete after several weeks, a higher dose can be tried under medical supervision.
Frequently asked questions
What is the standard starting dose of Sertraline? ▾
Most adults start Sertraline at the lowest strength of 25mg, 50mg, 100mg, with adjustment based on symptom response and tolerance. Older adults and those with reduced kidney or liver function generally start lower. The prescriber decides the exact starting dose for each person.
Can I take a higher dose of Sertraline if it isn't working? ▾
Higher doses of Sertraline should only be used after consulting the prescriber. Doubling on your own is unsafe, especially with active ingredients in the Selective serotonin reuptake inhibitor (SSRI) class. The prescriber can confirm whether titration is appropriate or whether the medication needs to be changed.
Products containing Sertraline
More on Sertraline
- With alcoholSertraline and alcohol — is it safe to drink?
- With foodShould Sertraline be taken with food?
- Side effectsSertraline side effects: common, rare and warning signs
- OnsetHow fast does Sertraline start working?
- DurationHow long does Sertraline last?
- Missed doseWhat to do if you miss a dose of Sertraline
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.