Selective serotonin reuptake inhibitor (SSRI)
How to stop taking Sertraline
Discontinuing Sertraline (Sertraline) is, for most people, safe and uneventful. For a few medications and indications, abrupt stopping can cause rebound symptoms, withdrawal-like effects or loss of disease control, so a tapered stop is preferred. Whether Sertraline at 25mg, 50mg, 100mg needs a taper depends on the active ingredient and the duration of use.
When to taper Sertraline
Tapering is generally preferred when Sertraline has been used continuously for months and the active ingredient Sertraline produces neuroadaptive changes that take time to reverse. Sertraline selectively blocks the reuptake of serotonin (5-HT) by the presynaptic neuron, increasing the concentration of serotonin in the synaptic cleft. For event-driven use, no taper is needed — simply stopping is appropriate. The prescriber decides the schedule based on the indication and dose.
What to expect when stopping
After stopping Sertraline at 25mg, 50mg, 100mg, the underlying condition may return as the medication washes out — this is loss of treatment effect, not withdrawal in the strict sense. Some active ingredients also produce specific discontinuation syndromes, which a tapered stop minimises. Persistent or severe symptoms after stopping deserve medical review.
Frequently asked questions
Can I just stop taking Sertraline? ▾
For event-driven use of Sertraline at 25mg, 50mg, 100mg, yes — simply stopping is fine. For chronic continuous use, abrupt stopping can be appropriate for some active ingredients and inadvisable for others. Confirm with the prescriber before stopping.
Will I have withdrawal from Sertraline? ▾
True withdrawal is uncommon with most Selective serotonin reuptake inhibitor (SSRI) agents. What is sometimes mistaken for withdrawal is the return of the underlying condition. The prescribing information for Sertraline lists any documented discontinuation effects to expect.
Products containing Sertraline
More on Sertraline
- With alcoholSertraline and alcohol — is it safe to drink?
- With foodShould Sertraline be taken with food?
- Side effectsSertraline side effects: common, rare and warning signs
- Dosage guideSertraline dosage guide: how much to take and when
- OnsetHow fast does Sertraline start working?
- DurationHow long does Sertraline last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.