Selective estrogen receptor modulator (SERM)
Raloxifene with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Raloxifene (Raloxifene). Most antibiotics do not interfere meaningfully with Raloxifene at 60mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Selective estrogen receptor modulator (SERM) agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Raloxifene at 60mg.
Practical guidance
According to the prescribing information for Raloxifene, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Raloxifene is co-administered. Adjusted 60mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Raloxifene during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Raloxifene is metabolised and may need a temporary 60mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Raloxifene regimen.
Will antibiotics make Raloxifene stop working? ▾
Most antibiotics do not affect Raloxifene efficacy. Rifampicin and a few others can lower Raloxifene levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Raloxifene
More on Raloxifene
- With alcoholRaloxifene and alcohol — is it safe to drink?
- With foodShould Raloxifene be taken with food?
- Side effectsRaloxifene side effects: common, rare and warning signs
- Dosage guideRaloxifene dosage guide: how much to take and when
- OnsetHow fast does Raloxifene start working?
- DurationHow long does Raloxifene last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.