Leukotriene receptor antagonist
Montelukast with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Montelukast (Montelukast). Most antibiotics do not interfere meaningfully with Montelukast at 4mg, 5mg, 10mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Leukotriene receptor antagonist agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Montelukast at 4mg, 5mg, 10mg.
Practical guidance
According to the prescribing information for Montelukast, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Montelukast is co-administered. Adjusted 4mg, 5mg, 10mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Montelukast during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Montelukast is metabolised and may need a temporary 4mg, 5mg, 10mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Montelukast regimen.
Will antibiotics make Montelukast stop working? ▾
Most antibiotics do not affect Montelukast efficacy. Rifampicin and a few others can lower Montelukast levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Montelukast
More on Montelukast
- With alcoholMontelukast and alcohol — is it safe to drink?
- With foodShould Montelukast be taken with food?
- Side effectsMontelukast side effects: common, rare and warning signs
- Dosage guideMontelukast dosage guide: how much to take and when
- OnsetHow fast does Montelukast start working?
- DurationHow long does Montelukast last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.