GLP-1 receptor agonist
Liraglutide with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Liraglutide (Liraglutide). The combination is generally fine at 6 mg/mL, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Liraglutide can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Liraglutide acts on CYP3A4 determines whether Liraglutide affects contraception. Most agents in GLP-1 receptor agonist have no clinically meaningful effect on the pill at 6 mg/mL.
Practical guidance
According to the prescribing information for Liraglutide, women on hormonal contraception should review Liraglutide with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Liraglutide therapy is the standard mitigation.
Frequently asked questions
Will Liraglutide make my pill less effective? ▾
Most GLP-1 receptor agonist medications at 6 mg/mL do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Liraglutide states whether the interaction is meaningful.
Do I need a backup contraceptive on Liraglutide? ▾
Backup contraception is needed only when there is a documented interaction between Liraglutide and the contraceptive method. For most users at 6 mg/mL, no backup is required. The pharmacist confirms whether Liraglutide interacts with hormonal contraception.
Products containing Liraglutide
More on Liraglutide
- With alcoholLiraglutide and alcohol — is it safe to drink?
- With foodShould Liraglutide be taken with food?
- Side effectsLiraglutide side effects: common, rare and warning signs
- Dosage guideLiraglutide dosage guide: how much to take and when
- OnsetHow fast does Liraglutide start working?
- DurationHow long does Liraglutide last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.