Long-acting beta-2 agonist (LABA)
Formoterol with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Formoterol (Formoterol). The combination is generally fine at 80/4.5 mcg, 160/4.5 mcg, 200/6 mcg, 400/12 mcg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Formoterol can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Formoterol acts on CYP3A4 determines whether Formoterol affects contraception. Most agents in Long-acting beta-2 agonist (LABA) have no clinically meaningful effect on the pill at 80/4.5 mcg, 160/4.5 mcg, 200/6 mcg, 400/12 mcg.
Practical guidance
According to the prescribing information for Formoterol, women on hormonal contraception should review Formoterol with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Formoterol therapy is the standard mitigation.
Frequently asked questions
Will Formoterol make my pill less effective? ▾
Most Long-acting beta-2 agonist (LABA) medications at 80/4.5 mcg, 160/4.5 mcg, 200/6 mcg, 400/12 mcg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Formoterol states whether the interaction is meaningful.
Do I need a backup contraceptive on Formoterol? ▾
Backup contraception is needed only when there is a documented interaction between Formoterol and the contraceptive method. For most users at 80/4.5 mcg, 160/4.5 mcg, 200/6 mcg, 400/12 mcg, no backup is required. The pharmacist confirms whether Formoterol interacts with hormonal contraception.
Products containing Formoterol
More on Formoterol
- With alcoholFormoterol and alcohol — is it safe to drink?
- With foodShould Formoterol be taken with food?
- Side effectsFormoterol side effects: common, rare and warning signs
- Dosage guideFormoterol dosage guide: how much to take and when
- OnsetHow fast does Formoterol start working?
- DurationHow long does Formoterol last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.