Multifunctional serotonin agonist/antagonist (HSDD)
Flibanserin with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Flibanserin (Flibanserin). The combination is generally fine at 100mg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Flibanserin can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Flibanserin acts on CYP3A4 determines whether Flibanserin affects contraception. Most agents in Multifunctional serotonin agonist/antagonist (HSDD) have no clinically meaningful effect on the pill at 100mg.
Practical guidance
According to the prescribing information for Flibanserin, women on hormonal contraception should review Flibanserin with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Flibanserin therapy is the standard mitigation.
Frequently asked questions
Will Flibanserin make my pill less effective? ▾
Most Multifunctional serotonin agonist/antagonist (HSDD) medications at 100mg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Flibanserin states whether the interaction is meaningful.
Do I need a backup contraceptive on Flibanserin? ▾
Backup contraception is needed only when there is a documented interaction between Flibanserin and the contraceptive method. For most users at 100mg, no backup is required. The pharmacist confirms whether Flibanserin interacts with hormonal contraception.
Products containing Flibanserin
More on Flibanserin
- With alcoholFlibanserin and alcohol — is it safe to drink?
- With foodShould Flibanserin be taken with food?
- Side effectsFlibanserin side effects: common, rare and warning signs
- Dosage guideFlibanserin dosage guide: how much to take and when
- OnsetHow fast does Flibanserin start working?
- DurationHow long does Flibanserin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.