Non-benzodiazepine hypnotic (Z-drug)
Eszopiclone with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Eszopiclone (Eszopiclone). Most antibiotics do not interfere meaningfully with Eszopiclone at 1mg, 2mg, 3mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Non-benzodiazepine hypnotic (Z-drug) agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Eszopiclone at 1mg, 2mg, 3mg.
Practical guidance
According to the prescribing information for Eszopiclone, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Eszopiclone is co-administered. Adjusted 1mg, 2mg, 3mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Eszopiclone during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Eszopiclone is metabolised and may need a temporary 1mg, 2mg, 3mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Eszopiclone regimen.
Will antibiotics make Eszopiclone stop working? ▾
Most antibiotics do not affect Eszopiclone efficacy. Rifampicin and a few others can lower Eszopiclone levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Eszopiclone
More on Eszopiclone
- With alcoholEszopiclone and alcohol — is it safe to drink?
- With foodShould Eszopiclone be taken with food?
- Side effectsEszopiclone side effects: common, rare and warning signs
- Dosage guideEszopiclone dosage guide: how much to take and when
- OnsetHow fast does Eszopiclone start working?
- DurationHow long does Eszopiclone last?
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