Serotonin-norepinephrine reuptake inhibitor (SNRI)
Who should not take Duloxetine
A contraindication is a condition under which Duloxetine (Duloxetine) should not be taken because the risk outweighs the benefit. Duloxetine has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 20mg, 30mg, 60mg dosing range.
Absolute contraindications
According to the prescribing information for Duloxetine, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Duloxetine can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Duloxetine inhibits the reuptake of both serotonin and norepinephrine at the synapse, with weaker effect on dopamine.
Frequently asked questions
Can someone with heart disease take Duloxetine? ▾
Some forms of heart disease are absolute contraindications for Duloxetine, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Duloxetine use under specialist supervision. The prescribing information for Duloxetine should be reviewed.
Is Duloxetine safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Duloxetine at adjusted lower 20mg, 30mg, 60mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Duloxetine
More on Duloxetine
- With alcoholDuloxetine and alcohol — is it safe to drink?
- With foodShould Duloxetine be taken with food?
- Side effectsDuloxetine side effects: common, rare and warning signs
- Dosage guideDuloxetine dosage guide: how much to take and when
- OnsetHow fast does Duloxetine start working?
- DurationHow long does Duloxetine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.