Short-acting SSRI (premature ejaculation)
Dapoxetine with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Dapoxetine (Dapoxetine). Most antibiotics do not interfere meaningfully with Dapoxetine at 30mg, 60mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Short-acting SSRI (premature ejaculation) agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Dapoxetine at 30mg, 60mg.
Practical guidance
According to the prescribing information for Dapoxetine, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Dapoxetine is co-administered. Adjusted 30mg, 60mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Dapoxetine during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Dapoxetine is metabolised and may need a temporary 30mg, 60mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Dapoxetine regimen.
Will antibiotics make Dapoxetine stop working? ▾
Most antibiotics do not affect Dapoxetine efficacy. Rifampicin and a few others can lower Dapoxetine levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Dapoxetine
More on Dapoxetine
- With alcoholDapoxetine and alcohol — is it safe to drink?
- With foodShould Dapoxetine be taken with food?
- Side effectsDapoxetine side effects: common, rare and warning signs
- Dosage guideDapoxetine dosage guide: how much to take and when
- OnsetHow fast does Dapoxetine start working?
- DurationHow long does Dapoxetine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.