P2Y12 receptor antagonist (antiplatelet)
Who should not take Clopidogrel
A contraindication is a condition under which Clopidogrel (Clopidogrel) should not be taken because the risk outweighs the benefit. Clopidogrel has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 75mg, 300mg dosing range.
Absolute contraindications
According to the prescribing information for Clopidogrel, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Clopidogrel can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Clopidogrel itself is inactive; the active metabolite, formed in the liver by CYP2C19 and other cytochromes, irreversibly binds the P2Y12 ADP receptor on platelets.
Frequently asked questions
Can someone with heart disease take Clopidogrel? ▾
Some forms of heart disease are absolute contraindications for Clopidogrel, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Clopidogrel use under specialist supervision. The prescribing information for Clopidogrel should be reviewed.
Is Clopidogrel safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Clopidogrel at adjusted lower 75mg, 300mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Clopidogrel
More on Clopidogrel
- With alcoholClopidogrel and alcohol — is it safe to drink?
- With foodShould Clopidogrel be taken with food?
- Side effectsClopidogrel side effects: common, rare and warning signs
- Dosage guideClopidogrel dosage guide: how much to take and when
- OnsetHow fast does Clopidogrel start working?
- DurationHow long does Clopidogrel last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.