Beta-lactamase inhibitor
Clavulanate with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Clavulanate (Clavulanate). The combination is generally fine at 500/125mg, 875/125mg, 1000/62.5mg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Clavulanate can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Clavulanate acts on CYP3A4 determines whether Clavulanate affects contraception. Most agents in Beta-lactamase inhibitor have no clinically meaningful effect on the pill at 500/125mg, 875/125mg, 1000/62.5mg.
Practical guidance
According to the prescribing information for Clavulanate, women on hormonal contraception should review Clavulanate with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Clavulanate therapy is the standard mitigation.
Frequently asked questions
Will Clavulanate make my pill less effective? ▾
Most Beta-lactamase inhibitor medications at 500/125mg, 875/125mg, 1000/62.5mg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Clavulanate states whether the interaction is meaningful.
Do I need a backup contraceptive on Clavulanate? ▾
Backup contraception is needed only when there is a documented interaction between Clavulanate and the contraceptive method. For most users at 500/125mg, 875/125mg, 1000/62.5mg, no backup is required. The pharmacist confirms whether Clavulanate interacts with hormonal contraception.
Products containing Clavulanate
More on Clavulanate
- With alcoholClavulanate and alcohol — is it safe to drink?
- With foodShould Clavulanate be taken with food?
- Side effectsClavulanate side effects: common, rare and warning signs
- Dosage guideClavulanate dosage guide: how much to take and when
- OnsetHow fast does Clavulanate start working?
- DurationHow long does Clavulanate last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.