Second-generation H1 antihistamine
Cetirizine with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Cetirizine (Cetirizine). Most antibiotics do not interfere meaningfully with Cetirizine at 5mg, 10mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Second-generation H1 antihistamine agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Cetirizine at 5mg, 10mg.
Practical guidance
According to the prescribing information for Cetirizine, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Cetirizine is co-administered. Adjusted 5mg, 10mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Cetirizine during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Cetirizine is metabolised and may need a temporary 5mg, 10mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Cetirizine regimen.
Will antibiotics make Cetirizine stop working? ▾
Most antibiotics do not affect Cetirizine efficacy. Rifampicin and a few others can lower Cetirizine levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Cetirizine
More on Cetirizine
- With alcoholCetirizine and alcohol — is it safe to drink?
- With foodShould Cetirizine be taken with food?
- Side effectsCetirizine side effects: common, rare and warning signs
- Dosage guideCetirizine dosage guide: how much to take and when
- OnsetHow fast does Cetirizine start working?
- DurationHow long does Cetirizine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.