COX-2 selective NSAID
Who should not take Celecoxib
A contraindication is a condition under which Celecoxib (Celecoxib) should not be taken because the risk outweighs the benefit. Celecoxib has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 50mg, 100mg, 200mg, 400mg dosing range.
Absolute contraindications
According to the prescribing information for Celecoxib, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Celecoxib can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Celecoxib selectively inhibits cyclooxygenase-2 (COX-2), the enzyme isoform induced at sites of inflammation, which produces the prostaglandins responsible for pain, fever and inflammation.
Frequently asked questions
Can someone with heart disease take Celecoxib? ▾
Some forms of heart disease are absolute contraindications for Celecoxib, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Celecoxib use under specialist supervision. The prescribing information for Celecoxib should be reviewed.
Is Celecoxib safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Celecoxib at adjusted lower 50mg, 100mg, 200mg, 400mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Celecoxib
More on Celecoxib
- With alcoholCelecoxib and alcohol — is it safe to drink?
- With foodShould Celecoxib be taken with food?
- Side effectsCelecoxib side effects: common, rare and warning signs
- Dosage guideCelecoxib dosage guide: how much to take and when
- OnsetHow fast does Celecoxib start working?
- DurationHow long does Celecoxib last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.