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Who should not take Amlodipine
A contraindication is a condition under which Amlodipine (Amlodipine) should not be taken because the risk outweighs the benefit. Amlodipine has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 2.5mg, 5mg, 10mg dosing range.
Absolute contraindications
According to the prescribing information for Amlodipine, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Amlodipine can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Amlodipine selectively blocks L-type calcium channels in vascular smooth muscle, reducing transmembrane calcium influx and producing peripheral arterial vasodilation.
Frequently asked questions
Can someone with heart disease take Amlodipine? ▾
Some forms of heart disease are absolute contraindications for Amlodipine, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Amlodipine use under specialist supervision. The prescribing information for Amlodipine should be reviewed.
Is Amlodipine safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Amlodipine at adjusted lower 2.5mg, 5mg, 10mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Amlodipine
More on Amlodipine
- With alcoholAmlodipine and alcohol — is it safe to drink?
- With foodShould Amlodipine be taken with food?
- Side effectsAmlodipine side effects: common, rare and warning signs
- Dosage guideAmlodipine dosage guide: how much to take and when
- OnsetHow fast does Amlodipine start working?
- DurationHow long does Amlodipine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.