Tricyclic antidepressant (TCA)
Who should not take Amitriptyline
A contraindication is a condition under which Amitriptyline (Amitriptyline) should not be taken because the risk outweighs the benefit. Amitriptyline has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 10mg, 25mg, 50mg, 75mg, 100mg dosing range.
Absolute contraindications
According to the prescribing information for Amitriptyline, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Amitriptyline can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Amitriptyline inhibits the reuptake of serotonin and noradrenaline at central synapses, raising synaptic levels of both neurotransmitters.
Frequently asked questions
Can someone with heart disease take Amitriptyline? ▾
Some forms of heart disease are absolute contraindications for Amitriptyline, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Amitriptyline use under specialist supervision. The prescribing information for Amitriptyline should be reviewed.
Is Amitriptyline safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Amitriptyline at adjusted lower 10mg, 25mg, 50mg, 75mg, 100mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Amitriptyline
More on Amitriptyline
- With alcoholAmitriptyline and alcohol — is it safe to drink?
- With foodShould Amitriptyline be taken with food?
- Side effectsAmitriptyline side effects: common, rare and warning signs
- Dosage guideAmitriptyline dosage guide: how much to take and when
- OnsetHow fast does Amitriptyline start working?
- DurationHow long does Amitriptyline last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.