Yasmin with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Yasmin (Drospirenone / Ethinyl Estradiol). The combination is generally fine at 3mg / 0.03mg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Yasmin can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Drospirenone, Ethinyl Estradiol acts on CYP3A4 determines whether Yasmin affects contraception. Most agents in Women's Sexual Health have no clinically meaningful effect on the pill at 3mg / 0.03mg.
Practical guidance
According to the prescribing information for Drospirenone, Ethinyl Estradiol, women on hormonal contraception should review Yasmin with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Yasmin therapy is the standard mitigation.
Frequently asked questions
Will Yasmin make my pill less effective? ▾
Most Women's Sexual Health medications at 3mg / 0.03mg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Drospirenone, Ethinyl Estradiol states whether the interaction is meaningful.
Do I need a backup contraceptive on Yasmin? ▾
Backup contraception is needed only when there is a documented interaction between Yasmin and the contraceptive method. For most users at 3mg / 0.03mg, no backup is required. The pharmacist confirms whether Drospirenone, Ethinyl Estradiol interacts with hormonal contraception.
More on Yasmin
- With alcoholYasmin and alcohol — is it safe to drink?
- With foodShould Yasmin be taken with food?
- Side effectsYasmin side effects: common, rare and warning signs
- Dosage guideYasmin dosage guide: how much to take and when
- OnsetHow fast does Yasmin start working?
- DurationHow long does Yasmin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.