Xalatan with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Xalatan (Latanoprost). The combination is generally fine at 0.005%, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Xalatan can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Latanoprost acts on CYP3A4 determines whether Xalatan affects contraception. Most agents in Eye Care and Ophthalmic Treatments have no clinically meaningful effect on the pill at 0.005%.
Practical guidance
According to the prescribing information for Latanoprost, women on hormonal contraception should review Xalatan with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Xalatan therapy is the standard mitigation.
Frequently asked questions
Will Xalatan make my pill less effective? ▾
Most Eye Care and Ophthalmic Treatments medications at 0.005% do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Latanoprost states whether the interaction is meaningful.
Do I need a backup contraceptive on Xalatan? ▾
Backup contraception is needed only when there is a documented interaction between Xalatan and the contraceptive method. For most users at 0.005%, no backup is required. The pharmacist confirms whether Latanoprost interacts with hormonal contraception.
More on Xalatan
- With alcoholXalatan and alcohol — is it safe to drink?
- With foodShould Xalatan be taken with food?
- Side effectsXalatan side effects: common, rare and warning signs
- Dosage guideXalatan dosage guide: how much to take and when
- OnsetHow fast does Xalatan start working?
- DurationHow long does Xalatan last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.