Singulair with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Singulair (Montelukast). Most antibiotics do not interfere meaningfully with Montelukast at 4mg, 5mg, 10mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Respiratory Medications agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Montelukast at 4mg, 5mg, 10mg.
Practical guidance
According to the prescribing information for Montelukast, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Singulair is co-administered. Adjusted 4mg, 5mg, 10mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Singulair during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Montelukast is metabolised and may need a temporary 4mg, 5mg, 10mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Singulair regimen.
Will antibiotics make Singulair stop working? ▾
Most antibiotics do not affect Singulair efficacy. Rifampicin and a few others can lower Montelukast levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Singulair
- With alcoholSingulair and alcohol — is it safe to drink?
- With foodShould Singulair be taken with food?
- Side effectsSingulair side effects: common, rare and warning signs
- Dosage guideSingulair dosage guide: how much to take and when
- OnsetHow fast does Singulair start working?
- DurationHow long does Singulair last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.