Who should not take Singulair
A contraindication is a condition under which Singulair (Montelukast) should not be taken because the risk outweighs the benefit. Singulair has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 4mg, 5mg, 10mg dosing range.
Absolute contraindications
According to the prescribing information for Montelukast, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Singulair can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Montelukast selectively blocks the CysLT1 receptor, which mediates the action of leukotrienes C4, D4 and E4 — proinflammatory mediators released by mast cells and eosinophils.
Frequently asked questions
Can someone with heart disease take Singulair? ▾
Some forms of heart disease are absolute contraindications for Singulair, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Singulair use under specialist supervision. The prescribing information for Montelukast should be reviewed.
Is Singulair safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Singulair at adjusted lower 4mg, 5mg, 10mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Singulair
- With alcoholSingulair and alcohol — is it safe to drink?
- With foodShould Singulair be taken with food?
- Side effectsSingulair side effects: common, rare and warning signs
- Dosage guideSingulair dosage guide: how much to take and when
- OnsetHow fast does Singulair start working?
- DurationHow long does Singulair last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.