Who should not take Saxenda

A contraindication is a condition under which Saxenda (Liraglutide) should not be taken because the risk outweighs the benefit. Saxenda has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 6 mg/mL dosing range.

Absolute contraindications

According to the prescribing information for Liraglutide, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.

Relative cautions

Relative cautions are situations where Saxenda can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Saxenda acts on the GLP-1 receptor in the central nervous system and gastrointestinal tract to reduce appetite, slow gastric emptying and increase satiety.

Frequently asked questions

Can someone with heart disease take Saxenda? ▾

Some forms of heart disease are absolute contraindications for Saxenda, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Saxenda use under specialist supervision. The prescribing information for Liraglutide should be reviewed.

Is Saxenda safe with kidney problems? ▾

Mild to moderate kidney impairment usually allows Saxenda at adjusted lower 6 mg/mL doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.

More on Saxenda

The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.