Restoril with antidepressants: interactions
Many adults take an antidepressant for mood, anxiety or chronic pain. The combination with Restoril (Temazepam) is common and, for most antidepressant classes, well tolerated. A few specific combinations require attention because of additive effects or shared metabolic pathways.
Antidepressant interaction landscape
SSRIs, SNRIs, TCAs, MAOIs and atypical antidepressants each interact differently. SSRIs are the most commonly co-prescribed and usually have minor or no clinically meaningful interaction with Temazepam at 7.5mg, 15mg, 22.5mg, 30mg. MAOIs require special caution with many medications. Tricyclics can amplify cardiovascular and sedative effects of some Sleep Aids and Hypnotics agents.
Practical guidance
According to the prescribing information for Temazepam, any change in antidepressant therapy should be reviewed alongside Restoril dosing. Switching antidepressants — particularly to or from MAOIs — usually requires a washout period before resuming Restoril at the standard 7.5mg, 15mg, 22.5mg, 30mg schedule.
Frequently asked questions
Can I take Restoril on an SSRI? ▾
For most SSRIs and most Sleep Aids and Hypnotics agents, the combination is acceptable with normal monitoring. A few combinations require dose adjustment or alternative selection. The prescriber confirms based on the specific antidepressant and the active ingredient Temazepam.
Are there antidepressants to avoid with Restoril? ▾
MAOIs are the antidepressant class most often flagged for caution with many medications. Other interactions depend on Temazepam and the specific antidepressant; a pharmacist review is the practical safeguard at 7.5mg, 15mg, 22.5mg, 30mg.
More on Restoril
- With alcoholRestoril and alcohol — is it safe to drink?
- With foodShould Restoril be taken with food?
- Side effectsRestoril side effects: common, rare and warning signs
- Dosage guideRestoril dosage guide: how much to take and when
- OnsetHow fast does Restoril start working?
- DurationHow long does Restoril last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.