Who should not take Provera
A contraindication is a condition under which Provera (Medroxyprogesterone Acetate) should not be taken because the risk outweighs the benefit. Provera has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 2.5mg, 5mg, 10mg dosing range.
Absolute contraindications
According to the prescribing information for Medroxyprogesterone, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Provera can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Medroxyprogesterone acetate binds progesterone receptors and produces strong progestational effects: thickening cervical mucus, inhibiting ovulation, thinning the endometrium and reducing endometrial…
Frequently asked questions
Can someone with heart disease take Provera? ▾
Some forms of heart disease are absolute contraindications for Provera, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Provera use under specialist supervision. The prescribing information for Medroxyprogesterone should be reviewed.
Is Provera safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Provera at adjusted lower 2.5mg, 5mg, 10mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Provera
- With alcoholProvera and alcohol — is it safe to drink?
- With foodShould Provera be taken with food?
- Side effectsProvera side effects: common, rare and warning signs
- Dosage guideProvera dosage guide: how much to take and when
- OnsetHow fast does Provera start working?
- DurationHow long does Provera last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.