Prometrium with kidney impairment: dosing and safety
Kidney function affects how the body clears Prometrium (Progesterone) and many of its metabolites. For people with chronic kidney disease, dialysis, or even mild renal impairment from age or comorbidities, the standard 100mg, 200mg dose may need adjustment. This page summarises the practical principles for Prometrium in renal impairment.
Why renal function matters for Prometrium
A meaningful fraction of Progesterone or its active metabolites is cleared by the kidneys for many medications. Reduced eGFR slows clearance, raises plasma concentrations and prolongs effect. Progesterone in Prometrium binds to progesterone receptors and modulates gene expression in reproductive and other tissues. The prescribing information for Progesterone usually specifies dose adjustments by eGFR threshold (e.g. 30–60 vs <30 mL/min/1.73m²).
Practical guidance
According to the prescribing information, baseline kidney function should be checked before starting Prometrium and periodically during treatment. People on dialysis need specialist input on dose timing relative to dialysis. Acute kidney injury — from dehydration, infection or other medications — can shift Prometrium effects unpredictably and may warrant a temporary hold at 100mg, 200mg.
Frequently asked questions
Is Prometrium safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Prometrium at adjusted lower 100mg, 200mg doses with monitoring. Severe impairment (eGFR <30) often requires substantial reduction or alternative therapy. The prescriber decides based on lab results and the indication.
Do I need lab tests on Prometrium if I have kidney disease? ▾
Yes — periodic eGFR and electrolyte monitoring is the standard practice for Prometrium in chronic kidney disease. Frequency depends on the severity of impairment and on Progesterone-specific risks. The prescriber sets the schedule.
More on Prometrium
- With alcoholPrometrium and alcohol — is it safe to drink?
- With foodShould Prometrium be taken with food?
- Side effectsPrometrium side effects: common, rare and warning signs
- Dosage guidePrometrium dosage guide: how much to take and when
- OnsetHow fast does Prometrium start working?
- DurationHow long does Prometrium last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.