Who should not take Prometrium
A contraindication is a condition under which Prometrium (Progesterone) should not be taken because the risk outweighs the benefit. Prometrium has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 100mg, 200mg dosing range.
Absolute contraindications
According to the prescribing information for Progesterone, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Prometrium can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Progesterone in Prometrium binds to progesterone receptors and modulates gene expression in reproductive and other tissues.
Frequently asked questions
Can someone with heart disease take Prometrium? ▾
Some forms of heart disease are absolute contraindications for Prometrium, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Prometrium use under specialist supervision. The prescribing information for Progesterone should be reviewed.
Is Prometrium safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Prometrium at adjusted lower 100mg, 200mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Prometrium
- With alcoholPrometrium and alcohol — is it safe to drink?
- With foodShould Prometrium be taken with food?
- Side effectsPrometrium side effects: common, rare and warning signs
- Dosage guidePrometrium dosage guide: how much to take and when
- OnsetHow fast does Prometrium start working?
- DurationHow long does Prometrium last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.