Norvasc with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Norvasc (Amlodipine). Most antibiotics do not interfere meaningfully with Amlodipine at 2.5mg, 5mg, 10mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Cardiovascular Medications agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Amlodipine at 2.5mg, 5mg, 10mg.
Practical guidance
According to the prescribing information for Amlodipine, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Norvasc is co-administered. Adjusted 2.5mg, 5mg, 10mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Norvasc during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Amlodipine is metabolised and may need a temporary 2.5mg, 5mg, 10mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Norvasc regimen.
Will antibiotics make Norvasc stop working? ▾
Most antibiotics do not affect Norvasc efficacy. Rifampicin and a few others can lower Amlodipine levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Norvasc
- With alcoholNorvasc and alcohol — is it safe to drink?
- With foodShould Norvasc be taken with food?
- Side effectsNorvasc side effects: common, rare and warning signs
- Dosage guideNorvasc dosage guide: how much to take and when
- OnsetHow fast does Norvasc start working?
- DurationHow long does Norvasc last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.