Lipitor with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Lipitor (Atorvastatin). Most antibiotics do not interfere meaningfully with Atorvastatin at 10mg, 20mg, 40mg, 80mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Cardiovascular Medications agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Atorvastatin at 10mg, 20mg, 40mg, 80mg.
Practical guidance
According to the prescribing information for Atorvastatin, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Lipitor is co-administered. Adjusted 10mg, 20mg, 40mg, 80mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Lipitor during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Atorvastatin is metabolised and may need a temporary 10mg, 20mg, 40mg, 80mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Lipitor regimen.
Will antibiotics make Lipitor stop working? ▾
Most antibiotics do not affect Lipitor efficacy. Rifampicin and a few others can lower Atorvastatin levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Lipitor
- With alcoholLipitor and alcohol — is it safe to drink?
- With foodShould Lipitor be taken with food?
- Side effectsLipitor side effects: common, rare and warning signs
- Dosage guideLipitor dosage guide: how much to take and when
- OnsetHow fast does Lipitor start working?
- DurationHow long does Lipitor last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.