Lamictal 25mg

Forms and dosages

Lamictal is administered orally once or twice daily, with or without food. According to the prescribing information, dose titration is critical and depends on co-administered antiepileptics. Typical adult monotherapy starts at 25mg daily for 2 weeks, then 50mg daily for 2 weeks, with subsequent increases to 100-200mg per day. When combined with valproate, slower titration and lower target doses are required. Slow titration minimises the risk of severe skin reactions.

Indications

Lamictal is approved in adults and children aged 2 years and older as adjunctive or monotherapy for partial-onset seizures, primary generalised tonic-clonic seizures and seizures associated with Lennox-Gastaut syndrome. It is also approved in adults for the maintenance treatment of bipolar I disorder, particularly to delay depressive episodes. According to international guidelines, Lamictal is one of the recommended agents in pregnancy because of its relatively favourable teratogenicity profile.