Klonopin with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Klonopin (Clonazepam). Most antibiotics do not interfere meaningfully with Clonazepam at 0.5mg, 1mg, 2mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Anti-anxiety Medications agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Clonazepam at 0.5mg, 1mg, 2mg.
Practical guidance
According to the prescribing information for Clonazepam, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Klonopin is co-administered. Adjusted 0.5mg, 1mg, 2mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Klonopin during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Clonazepam is metabolised and may need a temporary 0.5mg, 1mg, 2mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Klonopin regimen.
Will antibiotics make Klonopin stop working? ▾
Most antibiotics do not affect Klonopin efficacy. Rifampicin and a few others can lower Clonazepam levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Klonopin
- With alcoholKlonopin and alcohol — is it safe to drink?
- With foodShould Klonopin be taken with food?
- Side effectsKlonopin side effects: common, rare and warning signs
- Dosage guideKlonopin dosage guide: how much to take and when
- OnsetHow fast does Klonopin start working?
- DurationHow long does Klonopin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.