Januvia with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Januvia (Sitagliptin). The combination is generally fine at 25mg, 50mg, 100mg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Januvia can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Sitagliptin acts on CYP3A4 determines whether Januvia affects contraception. Most agents in Diabetes Treatment have no clinically meaningful effect on the pill at 25mg, 50mg, 100mg.
Practical guidance
According to the prescribing information for Sitagliptin, women on hormonal contraception should review Januvia with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Januvia therapy is the standard mitigation.
Frequently asked questions
Will Januvia make my pill less effective? ▾
Most Diabetes Treatment medications at 25mg, 50mg, 100mg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Sitagliptin states whether the interaction is meaningful.
Do I need a backup contraceptive on Januvia? ▾
Backup contraception is needed only when there is a documented interaction between Januvia and the contraceptive method. For most users at 25mg, 50mg, 100mg, no backup is required. The pharmacist confirms whether Sitagliptin interacts with hormonal contraception.
More on Januvia
- With alcoholJanuvia and alcohol — is it safe to drink?
- With foodShould Januvia be taken with food?
- Side effectsJanuvia side effects: common, rare and warning signs
- Dosage guideJanuvia dosage guide: how much to take and when
- OnsetHow fast does Januvia start working?
- DurationHow long does Januvia last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.