Who should not take Glucophage
A contraindication is a condition under which Glucophage (Metformin) should not be taken because the risk outweighs the benefit. Glucophage has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 500mg, 850mg, 1000mg dosing range.
Absolute contraindications
According to the prescribing information for Metformin, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Glucophage can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Metformin reduces hepatic glucose production through inhibition of mitochondrial complex I, which raises the cellular AMP/ATP ratio and activates AMP-activated protein kinase.
Frequently asked questions
Can someone with heart disease take Glucophage? ▾
Some forms of heart disease are absolute contraindications for Glucophage, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Glucophage use under specialist supervision. The prescribing information for Metformin should be reviewed.
Is Glucophage safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Glucophage at adjusted lower 500mg, 850mg, 1000mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Glucophage
- With alcoholGlucophage and alcohol — is it safe to drink?
- With foodShould Glucophage be taken with food?
- Side effectsGlucophage side effects: common, rare and warning signs
- Dosage guideGlucophage dosage guide: how much to take and when
- OnsetHow fast does Glucophage start working?
- DurationHow long does Glucophage last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.