Estrace with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Estrace (Estradiol). Most antibiotics do not interfere meaningfully with Estradiol at 0.5mg, 1mg, 2mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Hormones and Birth Control agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Estradiol at 0.5mg, 1mg, 2mg.
Practical guidance
According to the prescribing information for Estradiol, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Estrace is co-administered. Adjusted 0.5mg, 1mg, 2mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Estrace during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Estradiol is metabolised and may need a temporary 0.5mg, 1mg, 2mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Estrace regimen.
Will antibiotics make Estrace stop working? ▾
Most antibiotics do not affect Estrace efficacy. Rifampicin and a few others can lower Estradiol levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Estrace
- With alcoholEstrace and alcohol — is it safe to drink?
- With foodShould Estrace be taken with food?
- Side effectsEstrace side effects: common, rare and warning signs
- Dosage guideEstrace dosage guide: how much to take and when
- OnsetHow fast does Estrace start working?
- DurationHow long does Estrace last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.