Elavil 50mg

Forms and dosages

Amitriptyline is supplied as oral tablets in 10, 25, 50, 75 and 100mg strengths. For neuropathic pain or migraine prevention, typical dosing is 10–25mg at bedtime, titrated by 10–25mg every week or two as tolerated. For depression, doses of 75–150mg at bedtime are typical, divided initially during titration if needed. Take in the evening or at bedtime to align with the sedating effect.

Indications

Amitriptyline is approved for major depressive disorder, but contemporary use is dominated by low-dose off-label indications: neuropathic pain, fibromyalgia, chronic tension headache, migraine prevention, irritable bowel syndrome, nocturnal enuresis, and insomnia. According to current pain guidelines, low-dose amitriptyline is first-line for many neuropathic pain conditions. For depression, SSRIs are typically preferred first-line because of better tolerability and overdose safety.