Desyrel with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Desyrel (Trazodone). The combination is generally fine at 50mg, 100mg, 150mg, 300mg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Desyrel can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Trazodone acts on CYP3A4 determines whether Desyrel affects contraception. Most agents in Anti-Depressants have no clinically meaningful effect on the pill at 50mg, 100mg, 150mg, 300mg.
Practical guidance
According to the prescribing information for Trazodone, women on hormonal contraception should review Desyrel with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Desyrel therapy is the standard mitigation.
Frequently asked questions
Will Desyrel make my pill less effective? ▾
Most Anti-Depressants medications at 50mg, 100mg, 150mg, 300mg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Trazodone states whether the interaction is meaningful.
Do I need a backup contraceptive on Desyrel? ▾
Backup contraception is needed only when there is a documented interaction between Desyrel and the contraceptive method. For most users at 50mg, 100mg, 150mg, 300mg, no backup is required. The pharmacist confirms whether Trazodone interacts with hormonal contraception.
More on Desyrel
- With alcoholDesyrel and alcohol — is it safe to drink?
- With foodShould Desyrel be taken with food?
- Side effectsDesyrel side effects: common, rare and warning signs
- Dosage guideDesyrel dosage guide: how much to take and when
- OnsetHow fast does Desyrel start working?
- DurationHow long does Desyrel last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.