Demadex with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Demadex (Torsemide). Most antibiotics do not interfere meaningfully with Torsemide at 5mg, 10mg, 20mg, 100mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Diuretics agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Torsemide at 5mg, 10mg, 20mg, 100mg.
Practical guidance
According to the prescribing information for Torsemide, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Demadex is co-administered. Adjusted 5mg, 10mg, 20mg, 100mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Demadex during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Torsemide is metabolised and may need a temporary 5mg, 10mg, 20mg, 100mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Demadex regimen.
Will antibiotics make Demadex stop working? ▾
Most antibiotics do not affect Demadex efficacy. Rifampicin and a few others can lower Torsemide levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Demadex
- With alcoholDemadex and alcohol — is it safe to drink?
- With foodShould Demadex be taken with food?
- Side effectsDemadex side effects: common, rare and warning signs
- Dosage guideDemadex dosage guide: how much to take and when
- OnsetHow fast does Demadex start working?
- DurationHow long does Demadex last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.