Cialis with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Cialis (Tadalafil). Most antibiotics do not interfere meaningfully with Tadalafil at 2.5mg, 5mg, 10mg, 20mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Erectile Dysfunction (ED) agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Tadalafil at 2.5mg, 5mg, 10mg, 20mg.
Practical guidance
According to the prescribing information for Tadalafil, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Cialis is co-administered. Adjusted 2.5mg, 5mg, 10mg, 20mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Cialis during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Tadalafil is metabolised and may need a temporary 2.5mg, 5mg, 10mg, 20mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Cialis regimen.
Will antibiotics make Cialis stop working? ▾
Most antibiotics do not affect Cialis efficacy. Rifampicin and a few others can lower Tadalafil levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Cialis
- With alcoholCialis and alcohol — is it safe to drink?
- With foodShould Cialis be taken with food?
- Side effectsCialis side effects: common, rare and warning signs
- Dosage guideCialis dosage guide: how much to take and when
- OnsetHow fast does Cialis start working?
- DurationHow long does Cialis last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.