Buspar with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Buspar (Buspirone). Most antibiotics do not interfere meaningfully with Buspirone at 5mg, 7.5mg, 10mg, 15mg, 30mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Anti-anxiety Medications agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Buspirone at 5mg, 7.5mg, 10mg, 15mg, 30mg.
Practical guidance
According to the prescribing information for Buspirone, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Buspar is co-administered. Adjusted 5mg, 7.5mg, 10mg, 15mg, 30mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Buspar during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Buspirone is metabolised and may need a temporary 5mg, 7.5mg, 10mg, 15mg, 30mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Buspar regimen.
Will antibiotics make Buspar stop working? ▾
Most antibiotics do not affect Buspar efficacy. Rifampicin and a few others can lower Buspirone levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Buspar
- With alcoholBuspar and alcohol — is it safe to drink?
- With foodShould Buspar be taken with food?
- Side effectsBuspar side effects: common, rare and warning signs
- Dosage guideBuspar dosage guide: how much to take and when
- OnsetHow fast does Buspar start working?
- DurationHow long does Buspar last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.