AndroGel with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as AndroGel (Testosterone). The combination is generally fine at 1%, 1.62%, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How AndroGel can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Testosterone acts on CYP3A4 determines whether AndroGel affects contraception. Most agents in Hormones and Birth Control have no clinically meaningful effect on the pill at 1%, 1.62%.
Practical guidance
According to the prescribing information for Testosterone, women on hormonal contraception should review AndroGel with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of AndroGel therapy is the standard mitigation.
Frequently asked questions
Will AndroGel make my pill less effective? ▾
Most Hormones and Birth Control medications at 1%, 1.62% do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Testosterone states whether the interaction is meaningful.
Do I need a backup contraceptive on AndroGel? ▾
Backup contraception is needed only when there is a documented interaction between AndroGel and the contraceptive method. For most users at 1%, 1.62%, no backup is required. The pharmacist confirms whether Testosterone interacts with hormonal contraception.
More on AndroGel
- With alcoholAndroGel and alcohol — is it safe to drink?
- With foodShould AndroGel be taken with food?
- Side effectsAndroGel side effects: common, rare and warning signs
- Dosage guideAndroGel dosage guide: how much to take and when
- OnsetHow fast does AndroGel start working?
- DurationHow long does AndroGel last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.