Amoxil with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Amoxil (Amoxicillin). Most antibiotics do not interfere meaningfully with Amoxicillin at 250mg, 500mg, 875mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Antibiotics agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Amoxicillin at 250mg, 500mg, 875mg.
Practical guidance
According to the prescribing information for Amoxicillin, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Amoxil is co-administered. Adjusted 250mg, 500mg, 875mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Amoxil during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Amoxicillin is metabolised and may need a temporary 250mg, 500mg, 875mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Amoxil regimen.
Will antibiotics make Amoxil stop working? ▾
Most antibiotics do not affect Amoxil efficacy. Rifampicin and a few others can lower Amoxicillin levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Amoxil
- With alcoholAmoxil and alcohol — is it safe to drink?
- With foodShould Amoxil be taken with food?
- Side effectsAmoxil side effects: common, rare and warning signs
- Dosage guideAmoxil dosage guide: how much to take and when
- OnsetHow fast does Amoxil start working?
- DurationHow long does Amoxil last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.